Application Scenarios of Automated Plate Heat Sealer|News & Events|Hangzhou Allsheng Instruments

Application Scenarios of Automated Plate Heat Sealer

Release time：2025-07-16 ALLSHENG

Source：

Pageviews：178

Heat sealing is the "gold standard" method for sealing various well plates in the field of biomedicine. Common well plates include different types of PCR plates, sample storage deepwell plates, nucleic acid extraction deepwell plates, ELISA plates, and cell culture plates. The plate sealer seals the plate by heating to prevent sample or reagent evaporation and contamination.

In practical applications, compared to the methods of sealing and adhesive film, heat sealing film can more effectively reduce the loss caused by sample volatilization and prevent cross-contamination, showing greater advantages in time and economic costs.

SealBio-1 can be adapted to ANSI, SBS standard plates with height range of 3~62mm. It supports the use of 78-82mm heat sealing roll film. It also supports sealing of Auto-Pure series large-volume specialized cartridges. It can be widely used in application scenarios such as pre-filled reagents, sealing film before PCR, and sample preservation.

微信图片_2025-07-16_084744_359-en.jpg

Performance Testing

① Take 10×96 deepwell plates and weigh the empty plates on a balance (unit: g)

② Add 400μL of 80% ethanol to each well in plates 1 and 2, and weigh the plate + ethanol

③ Add 600μL of 80% ethanol to each well in plates 3 and 4, and weigh the plate + ethanol

④ Add 700μL of ultrapure water to each well in plates 5-10 and weigh them

⑤ After weighing, transfer to the SealBio-1 automated plate heat sealer for sealing, and weigh the total mass after sealing

⑥ Transfer to an environment with 45℃ and 50% humidity for 72 hours, with 1, 3, 5, 7, and 9 placed upright and 2, 4, 6, 8, and 10 inverted

Take out the weight and record the total mass

Table 1 Test Data of SealBio-1 Automated Plate Heat Sealer

No.	Empty plate weight	Plate + liquid weight	Total weight after sealing	Total weight after processing	Difference
1	98.7391	132.3205	132.8870	132.8191	-0.0679
2	98.6991	132.6491	133.2218	133.1604	-0.0614
3	99.9472	150.3822	150.9489	150.9005	-0.0484
4	99.0249	150.3385	150.9034	150.8503	-0.0531
5	98.7439	163.6300	164.1943	164.1267	-0.0676
6	98.7335	163.7393	164.3057	164.2672	-0.0385
7	99.0522	164.0015	164.5680	164.5325	-0.0355
8	98.7862	163.6128	164.1784	164.1438	-0.0346
9	99.1080	164.1856	164.7530	164.7145	-0.0385
10	99.4039	164.2744	164.8375	164.7965	-0.0410

The test results show that the weight reduction of 80% ethanol and pure water in both upright and inverted sealed deepwell plates is less than 0.1g. SealBio-1 automated plate heat sealer, equipped with a puncturable aluminum film, has a good sealing effect on deepwell plates and can meet the sealing storage requirements of reagents or samples and other types of liquids.

Common Application Scenarios

1 Molecular Biology

PCR experiment: used to seal PCR plates to prevent sample evaporation or contamination, ensuring the accuracy of amplification reactions.

DNA/RNA sequencing: seal the sample plate before sequencing to avoid sample degradation or contamination.

2 Cell Culture

Cell culture plate sealing: during cell culture, sealing the culture plate prevents evaporation and contamination of the culture medium, ensuring a stable environment for cell growth.

Long term storage: seal the cell culture plate for long-term preservation to avoid sample inactivation or contamination.

3 Drug Screening

High-throughput screening: seal the microplate in drug screening to prevent sample evaporation or cross-contamination, ensuring the reliability of experimental results.

Compound storage: seal the compound storage plate to ensure the stability of the compound during storage.

4 Clinical Diagnosis

ELISA experiment: seal the microplate in the ELISA experiment to prevent sample evaporation or contamination, ensuring accurate detection results.

Blood/urine sample storage: seal the sample plate to ensure that the sample is not contaminated or evaporated before testing.

In addition, automated plate heat sealers are widely used in microbiology, vaccine development, biological sample banks, food safety testing, environmental monitoring, proteomics research, and long-term experiments.

SealBio-1 is a standard microplate sealing design that can meet the requirements of efficient, stable, and reliable sealing. It can be used not only in the laboratory but also integrated into automated systems.

Back to list Previous：Assisting in the New Standard of Food Safety Testing Next：GeneCE-100 Biological Fragment Analysis System, Supports Your Experiments